Melatonin: Another avenue for treating osteoporosis?

Treating osteoporosis.

Marine Natural Products: New Avenue in Treatment of Osteoporosis

Bone metabolism is a physiological process that maintains the skeletal integrity and bone functions. Skeletal integrity is always balanced by two key cell types—bone resorbing osteoclasts and bone-forming osteoblasts. Imbalance between generation and function of osteoclasts and osteoblasts often leads to pathological conditions such as osteoporosis, osteopetrosis, Paget’s disease. Osteoporosis ...

Treating Osteoporosis with Oestrogen or Testosterone

A research from 1983 examined the necessary dosage of oestrogen in treatment of postmenopausal bone loss and showed patients to experience bone loss in doses up to 15 micrograms and bone gain in doses above 25 micrograms of oestrogen [6]. It’s therefore plausible to assume the likely effectiveness of testosterone treatment to Osteoporotic men and of oestrogen treatment to osteoporotic women pos...

Carbohydrate-based species recognition in sea urchin fertilization: another avenue for speciation?

Spawning marine invertebrates are excellent models for studying fertilization and reproductive isolating mechanisms. To identify variation in the major steps in sea urchin gamete recognition, we studied sperm activation in three closely related sympatric Strongylocentrotus species. Sperm undergo acrosomal exocytosis upon contact with sulfated polysaccharides in the egg-jelly coat. This acrosome...

Melatonin suppresses autophagy in type 2 diabetic osteoporosis

Type 2 diabetes mellitus is often complicated by osteoporosis, a process which may involve osteoblast autophagy. As melatonin suppresses autophagy under certain conditions, we its investigated the effects on bone autophagy during diabetes. We first assessed different body parameters in a diabetic rat model treated with various concentrations of melatonin. Dynamic biomechanicalmeasurements, bone...